Study on the Optimum Parameters of Alternating Magnetic Field Treatments against Cerebral Ischemia/Reperfusion Injury in Rats
Background and Aim: Cerebral ischemia/reperfusion injury is a major cause of acute brain injury. The pathogenetic mechanisms underlying ischemia/ reperfusion injury involve apoptosis, inflammation and oxidative stress. The aim of this study is to clarify the optimum parameters of low-frequency alternating magnetic field treatment for the functional recovery after MCAO reperfusion injury in rats by using Taguchi method. Methods: Brain samples from ischemic hemisphere were removed and weighed to measure the brain water content as brain water content is considered as index to estimate the ischemic-reperfusion injury. Results: Neuroprotective effects of low-frequency alternating magnetic fields after the middle cerebral artery occlusion reperfusion injury in rats are most likely to be exerted on parameters with intensity of 15mT, frequency of 20Hz and duration of 15 min for one time. Conclusion: Contribution ratio of frequency among parameters of alternating magnetic field is the highest for neuroprotective effects.